Table 2.
Echocardiographic parameters in female WT and P2X4R Tg animals
| Time Points After MI | n | FS, % | LVPW Thickening, mm | LVEDD, mm | LVESD, mm | MI Size, % |
|---|---|---|---|---|---|---|
| 7 days | ||||||
| WT | 28 | 20.50±0.59† | 0.059±0.0047† | 3.87±0.0840† | 3.08±0.0770† | 40.4±4.02† |
| P2X4R Tg | 21 | 22.60±0.84* | 0.079±0.0100* | 3.91±0.0970† | 3.05±0.0850† | 38.3±3.37 |
| 1 mo | ||||||
| WT | 19 | 18.80±0.59 | 0.053±0.0055 | 3.91±0.1100 | 3.18±0.0950 | 43.2±2.90 |
| P2X4R Tg | 14 | 24.20±0.77* | 0.080±0.0100* | 4.19±0.1350 | 3.19±0.1220 | 40.5±3.14 |
| 2 mo | ||||||
| WT | 22 | 18.49±0.56 | 0.040±0.0052 | 4.27±0.1600 | 3.51±0.1430 | 27.0±2.03 |
| P2X4R Tg | 17 | 23.14±0.76* | 0.102±0.0140* | 4.39±0.1590 | 3.39±0.1370 | 30.5±3.20 |
Values are means ± SE. At 7 days, 1 mo, and 2 mo after LAD ligation-induced myocardial infarction, WT and P2X4R Tg mice of either sex were subjected to echocardiography as described in methods. The various echocardiographic measurements were obtained as shown.
*
P < 0.05 vs. WT mice at the same time point after MI.
†
P < 0.05 vs. the 2-mo time point.