Table 3.
Echocardiographic parameters in male WT and P2X4R Tg animals
| Time Points After MI | n | FS, % | LVPW Thickening, mm | LVEDD, mm | LVESD, mm | MI Size, % |
|---|---|---|---|---|---|---|
| 7 days | ||||||
| WT | 28 | 17.65±0.49 | 0.051±0.0047 | 4.34±0.0870 | 3.53±0.10 | 44.8±3.67† |
| P2X4R Tg | 21 | 24.50±0.95*† | 0.090±0.0083* | 3.98±0.1600* | 3.14±0.13* | 38.1±4.22 |
| 1 mo | ||||||
| WT | 14 | 18.23±0.85 | 0.035±0.0056 | 4.33±0.1500 | 3.57±0.14 | 44.0±1.92 |
| P2X4R Tg | 10 | 22.72±1.14* | 0.090±0.0160* | 4.57±0.2190 | 3.55±0.21 | 42.3±1.83 |
| 2 mo | ||||||
| WT | 23 | 17.15±0.88 | 0.053±0.0055 | 4.29±0.1600 | 3.53±0.15 | 31.9±1.73 |
| P2X4R Tg | 18 | 20.42±0.98* | 0.087±0.0096* | 4.62±0.2900 | 3.68±0.26 | 33.6±4.90 |
Values are means ± SE. At 7 days, 1 mo, and 2 mo after LAD ligation-induced myocardial infarction, WT and P2X4R Tg mice of either sex were subjected to echocardiography as described in methods. The various echocardiographic measurements were obtained as shown.
*
P < 0.05 vs. WT mice at the same time point after MI.
†
P < 0.05 vs. the 2-mo time point.