Table 1.

Hemodynamic variables in the CTRL, IAA, and HI + HG groups under aerobic conditions and during 60% myocardial ischemia

	CTRL		IAA		HI + HG
	Baseline	Ischemia	Baseline	Ischemia	Baseline	Ischemia
Heart rate, beats/min	118±6	128±9	129±8	129±7	123±8	131±5
Peak LVP, mmHg	93±4	84±2†	86±5	83±5	90±3	89±2
dP/dtmax, mmHg/s	1,870±156	1,799±107	1,902±183	1,959±154	2,102±134	1,999±182
dP/dtmin, mmHg/s	−1,305±99	−1,086±106	−1,206±133	−1,093±84	−1,212±125	−1,163±106
MV̇o2, μmol·g−1·min−1	3.5±0.2	1.3±0.2‡	2.3±0.2*	1.0±0.1‡	3.1±0.2	1.4±0.2‡
Rate pressure product, mmHg·beat −1·min−1	11,000±900	10,800±1,000	11,000±800	10,200±600	11,300±1100	11,500±800

Values are means ± SE. CTRL, control; IAA, iodoacetate, HI + HG, hyperinsulinemia + hyperglycemia; LVP, left ventricular pressure; dP/dt_max and dP/dt_min, maximum and minimum first derivative of pressure, respectively; MV̇o₂, myocardial oxygen consumption.

^*P < 0.01 vs. CTRL;

^†P < 0.01 vs. baseline;

^‡P < 0.001 vs. baseline.