Fig. 1.

Schematics of the mechanobiochemical feedback mechanism. (A) Qualitative picture of the proposed mechanism. The sister-chromatid movements modulate the kinetochore resistance that results in chromosome stretching, which further affects the local chemical reactions that promote the AP movement of the chromatid. That, in turn, opposes the tendency of the P movement of the chromatid, leading to a closed feedback loop. (B) Two possible schemes of the local chemical reactions that govern feedback from the chromatid's mechanical state.