Table 5.
Insulin sensitivity phenotypes according to FOXO3A genotype
|
FOXO3A Genotype (rs 2802292) |
P* | |||
|---|---|---|---|---|
| TT | TG | GG | ||
| Fasting glucose, mg/dl | ||||
| Average-lived | 118.4 ± 34.0 | 117.4 ± 38.0 | 115.9 ± 40.1 | 0.80 |
| Long-lived | 108.3 ± 20.7 | 109.1 ± 23.7 | 110.5 ± 24.1 | 0.73 |
| Fasting insulin, mIU/liter | ||||
| Average-lived | 23.7 ± 81.2 | 30.4 ± 91.9 | 13.2 ± 5.9 | 0.004 |
| Long-lived | 13.5 ± 9.0 | 14.1 ± 13.4 | 13.3 ± 9.3 | 0.77 |
| Log fasting insulin, mIU/liter | ||||
| Average-lived | 2.68 ± 0.67 | 2.73 ± 0.85 | 2.47 ± 0.48 | 0.03 |
| Long-lived | 2.45 ± 0.55 | 2.43 ± 0.61 | 2.44 ± 0.52 | 0.99 |
| HOMA IR Score | ||||
| Average-lived | 9.1 ± 53.0 | 10.0 ± 32.2 | 3.8 ± 2.4 | 0.03 |
| Long-lived | 3.7 ± 2.8 | 4.0 ± 4.3 | 3.6 ± 2.2 | 0.55 |
*P value for Student's t test comparing mean values between GG genotype and other groups within cases and controls.