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. 2008 Sep 9;105(37):14011–14016. doi: 10.1073/pnas.0806616105

Fig. 3.

Fig. 3.

Aire induces both a known and a novel Aire signature in islets. (A) Scatterplot of a FC induced by Aire in islets (y axis) and MECs (x axis). Islet-specific and MEC-specific Aire-regulated genes are shown on gates a and b, respectively; commonly up-regulated or down-regulated genes are shown on gate c. The gray lines represent a FC of 2 or 0.5. (B) MEC Aire-signature (FC >2) highlighted in red over the FC versus mean expression value plot in islets. (C) MEC Aire-signature (FC <2) highlighted in green over the FC versus mean expression value plot of islets. (D) Mean FC distribution in RIP-Aire (red) and MEC (black) over 300 windows ranked by Aire MEC FC. The horizontal line represents the P = 0.05 significance threshold. (E) Significance of the bias represented in D and F, assessed by t test P value. (F) Bias of the FC distribution over the gene windows defined in D.