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. 2008 Sep 8;105(37):14070–14075. doi: 10.1073/pnas.0806993105

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© 2008 by The National Academy of Sciences of the USA

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Fig. 1. — Hyperleptinemia reverses abnormalities of uncontrolled autoimmune diabetes in the absence of insulin. Comparison of mean (± SEM) leptin levels (A), blood glucose levels (B), body weight and food intake (shaded dark area = Adv-leptin) (C), and plasma glucagon levels (D) in diabetic NOD mice after either treatment with Adv-leptin (■) (n = 9) or injection of Adv-β-gal (□) as a control (n = 6). Plasma glucagon levels of diabetic NOD mice were obtained 30 days after treatment with Adv-leptin (■) (n = 9) or injection of Adv-β-gal (□) (n = 6). Glucagon levels of prediabetic NOD mice (n = 6) are also displayed (). *, P < 0.01.

Inline graphic — Hyperleptinemia reverses abnormalities of uncontrolled autoimmune diabetes in the absence of insulin. Comparison of mean (± SEM) leptin levels (A), blood glucose levels (B), body weight and food intake (shaded dark area = Adv-leptin) (C), and plasma glucagon levels (D) in diabetic NOD mice after either treatment with Adv-leptin (■) (n = 9) or injection of Adv-β-gal (□) as a control (n = 6). Plasma glucagon levels of diabetic NOD mice were obtained 30 days after treatment with Adv-leptin (■) (n = 9) or injection of Adv-β-gal (□) (n = 6). Glucagon levels of prediabetic NOD mice (n = 6) are also displayed (). *, P < 0.01.