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Hyperleptinemia reverses abnormalities of uncontrolled diabetes induced by a double dose of STZ. (A) Comparison of mean (± SEM) blood glucose levels treated with Adv-leptin (■) (n = 5) or untreated double-dose STZ-diabetic rats (○) (n = 5). (B) Morphometric comparison of insulin-positive cells (mean ± SEM) in pancreata of 4 untreated diabetic rats, 5 Adv-leptin-treated STZ-diabetic rats, and 3 normal nondiabetic controls. (C) Plasma glucagon levels 30 days after treatment (*, P < 0.01).
