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. 2008 Sep 8;105(37):14181–14186. doi: 10.1073/pnas.0803893105

Fig. 1.

Fig. 1.

Transient and sustained light responses in dopaminergic amacrine neurons. (A and B) Extracellular loose patch recordings from a representative transient DA neuron (A) and representative sustained DA neuron (B). (Upper) Spike recordings made before and during L-AP4 application (50 μM). (Lower) Corresponding peri-stimulus time histograms (PSTH, bin width: 300 ms in A, 500 ms in B) before and during L-AP4 application. Bars indicate light on (open bar, duration 3 s, intensity −2 log I) and light off (filled bar). Dashed lines indicate prestimulus baseline. (C–E) Whole-cell voltage clamp recordings of light responses from transient and sustained DA neurons. Light-evoked excitatory inward currents in a transient DA neuron were blocked (C), whereas those in a sustained DA neuron were resistant to 75 μM L-AP4 (D), and L-AP4-resistant currents in a sustained DA neuron were blocked by 40 μM DNQX (E). Stimulus duration 3 s, intensity −1 log I in C and −2 log I in D and E.