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. 2008 Sep 8;105(37):14181–14186. doi: 10.1073/pnas.0803893105

Fig. 3.

Fig. 3.

L-AP4 resistant light responses of DA neurons persist in rod/cone degenerate retinas. (A) DA neuron loose patch recording from a 13-month-old rd1 mouse retina showing light response and persistence in the presence of 50 μM L-AP4. Representative examples of recordings made before (Left) and during (Right) L-AP4 application. (B) Average PSTH before and during L-AP4 application (bin width: 300 ms, n = 6, intensity −2 log I). (C) Average PSTH of DA neuron discharge to light stimuli (duration: 60 s, intensity −2 log I) in the presence of L-AP4 (bin width: 1000 ms, n = 4). (D) Latency of the peak of the light response was long in duration and decreased as light intensity increased (n = 5, 10 s duration). (Inset) Example Gaussian fit of spike frequency to determine latency (see SI Methods). (E) Blockade of light responses with CNQX (100 μM, intensity −2 log I).