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Domain structures of the three classes of ADF-H domain proteins. The ADF/cofilin proteins are composed of a single ADF-H domain. Twinfilins are composed of two ADF-H domains arranged in tandem. Members of the drebrin/Abp1 class have an ADF-H domain at the N-terminus of the protein, followed by a variable region and a C-terminal SH3 domain.
