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Sequence and secondary structure of a designed conformation-switching anti-PDGF aptamer. (A) Inactive conformation in the absence of PDGF. (B) Active conformation in the presence of PDGF. While the active conformation of the anti-thrombin aptamer is a quadruplex, the active conformation of the anti-PDGF aptamer is a multihelix junction. Features of the design are as in Figure 1.
