Table 1.
Demographic and Neuropsychological Variables for bvFTD Patient Groups and Controlsa
| Patients With bvFTD |
|||||
|---|---|---|---|---|---|
| Variable | Controls | CDR Score of 0.5 | CDR Score of 1 | CDR Score of 2-3 | Overall ANOVA |
| Age, y | 68.3 (7.9) | 65.9 (8.3) | 64.3 (8.9) | 62.3 (10.3) | F3,86=2.16 |
| Educational level, y | 16.4 (2.4) | 14.7 (3.3) | 15.9 (2.3) | 14.5 (2.4) | F3,86=3.00 |
| Male/female, No. | 23/22 | 9/6 | 10/5 | 7/8 | |
| Duration of symptoms, y | 5.8 (4.8) | 4.7 (3.6) | 6.1 (3.2) | F2,42=0.54 | |
| CDR box score sum | 0.0 (0.0) | 3.6 (2.3)b,c | 6.1 (1.4)c,d | 11.5 (2.5)b,c | F2,42=46.8e |
| MMSE score [range] (maximum score, 30) | 29.5 (0.7) [27-30] | 26.7 (3.1) [20-30]c | 23.3 (7.9) [2-29]c,f | 15.7 (7.7) [0-27]b,d,f | F3,84=33.9e |
| CVLT-SF, 4 trials, score (maximum score, 28) | 29.5 (3.8) | 19.6 (4.4)c,f | 18.1 (7.0)c,f | 9.3 (7.9)b,d,f | F3,75=52.0e |
| CVLT-SF, 10-minute recall, score (maximum score, 9) | 7.3 (1.6) | 3.0 (1.9)c,f | 4.1 (2.4)c,f | 0.7 (0.9)b,d,f | F3,71=47.9e |
| Modified Rey-Osterrieth copy score (maximum score, 17) | 15.8 (1.4) | 14.6 (1.8)c | 14.9 (1.8)c | 11.2 (5.4)b,d,f | F3,80=11.0e |
| Modified Rey-Osterrieth delay score (maximum score, 17) | 12.5 (3.1) | 7.1 (4.1)c,f | 5.7 (4.0)c,f | 1.8 (2.7)b,d,f | F3,79=37.6e |
| Digit span backward score | 5.3 (1.2) | 3.9 (1.1)f | 3.7 (1.9)f | 2.8 (2.4)f | F3,81=11.2e |
| Modified Trails B score (correct lines in 1 minute) | 32.4 (12.2) | 13.5 (15.5)f | 11.8 (14.3)f | 7.3 (8.8)f | F3,76=19.4e |
| Stroop interference task score (correct in 1 minute) | 55.1 (15.3) | 33.0 (24.9)f | 28.6 (16.9)f | 22.4 (16.1)f | F3,71=13.8e |
| Design fluency score (correct in 1 minute) | 11.2 (2.5) | 6.1 (4.0)f | 5.5 (2.7)f | 3.6 (3.5)f | F3,69=26.9e |
| Phonemic fluency score (D words generated in 1 minute) | 15.5 (4.6) | 8.2 (5.7)f | 5.8 (4.2)f | 3.8 (4.0)f | F3,81=31.5e |
| Semantic fluency score (animals generated in 1 minute) | 22.8 (5.3) | 10.0 (6.3)c,f | 8.8 (5.4)f | 4.6 (4.2)d,f | F3,83=57.5e |
| Abbreviated BNT score (maximum score, 15) | 14.6 (0.7) | 11.2 (3.7)f | 11.3 (4.5)f | 8.7 (3.7)f | F3,83=17.4e |
| Calculations score (maximum score, 5) | 4.8 (0.4) | 4.1 (1.2)c | 3.5 (1.8)f | 2.5 (1.5)d,f | F3,82=16.9e |
Abbreviations: ANOVA, analysis of variance; BNT, Boston Naming Test; bvFTD, behavioral variant frontotemporal dementia; CDR, Clinical Dementia Rating; CVLT-SF, California Verbal Learning Test–Short Form; MMSE, Mini-Mental State Examination.
a
Data are presented as mean (SD) unless otherwise indicated.
b
P< .05 vs CDR score of 1.
c
P< .05 vs CDR score of 2 to 3.
d
P< .05 vs CDR score of 0.5.
e
P< .01 across groups.
f
P< .05 vs controls.