eTable.
Regions of Gray Matter Loss in Very Mild, Mild, and Moderate to Severe bvFTD
| CDR Score |
|||||||
|---|---|---|---|---|---|---|---|
| 0.5 |
1 |
2-3 |
|||||
| Region | BA | x, y, z | z Score | x, y, z | z Score | x, y, z | z Score |
| Paralimbic | |||||||
| R pregenual ACC | 24 | 2, 36, 14 | 5.79 | 4, 38, 20 | 5.66 | 2, 28, 18 | 6.68 |
| L pregenual ACC | 24 | −2, 36, 12 | 5.83 | −2, 38, 16 | 5.06 | −2, 32, 16 | 6.61 |
| R paracingulate | 32 | 2, 44, 20 | 5.79 | 2, 44, 30 | 5.92 | 2, 44, 28 | 6.81 |
| L paracingulate | 32 | −2, 48, 22 | 5.38 | −2, 46, 28 | 5.98 | −2, 46, 24 | 5.96 |
| R rostromedial SFG | 10 | 2, 53, −4 | 5.89 | −2, 58, 2 | 5.83 | 1, 53, −3 | 6.82 |
| L rostromedial SFG | 10 | −2, 54, −4 | 5.52 | −2, 54, −2 | 5.57 | −2, 54, −4 | 6.62 |
| R subgenual ACC | 25 | 2, 8, −4 | 5.44 | 4, 8, −8 | 5.43 | 4, 8, −6 | 7.05 |
| L subgenual ACC | 25 | −4, 12, −6 | 4.85 | −4, 8, −6 | 5.20 | −4, 10, −6 | 6.88 |
| R frontal insula | 47/12 | 42, 17, −10 | 5.46 | 36, 18, −8 | 5.58 | 42, 16, −12 | 6.80 |
| L frontal insula | 47/12 | −39, 17, −13 | 5.44 | −38, 20, −10 | 5.18 | −39, 17, −13 | 6.92 |
| R dorsal anterior insula | NA | 39, 23, 5 | 5.61 | 35, 18, 5 | 6.97 | 35, 16, 7 | 7.22 |
| L dorsal anterior insula | NA | −34, 24, 4 | 4.98 | −32, 22, 4 | 6.05 | −36, 24, 4 | 6.68 |
| R lateral orbital gyrus | 47/11 | 33, 36, −13 | 4.66 | 34, 36, −13 | 5.72 | 42, 16, −12 | 6.80 |
| L lateral orbital gyrus | 47/11 | −29, 38, −13 | 4.86 | −29, 38, −14 | 6.00 | −30, 38, −15 | 5.60 |
| R posterior insula | NA | 44, −10, −4 | 6.55 | ||||
| L posterior insula | NA | −40, −12, −2 | 5.40 | ||||
| Neocortical | |||||||
| R frontal pole | 11 | 28, 61, −15 | 5.85 | 24, 61, −13 | 4.81 | 33, 63, −6 | 6.10 |
| L frontal pole | 11 | −31, 61, −2 | 5.67 | −29, 61, −2 | 6.78 | −27, 61, −3 | 6.31 |
| R MFG, ventral | 46 | 30, 52, 18 | 5.18 | 38, 52, 6 | 5.43 | 36, 44, 28 | 5.37 |
| L MFG, ventral | 46 | −42, 52, 9 | 4.84 | −42, 53, 7 | 5.87 | −45, 53, 4 | 6.60 |
| R IFG, opercularis | 44 | 38, 14, 33 | 5.13 | 38, 15, 33 | 6.57 | 38, 13, 34 | 6.76 |
| L IFG, opercularis | 44 | −44, 13, 28 | 5.70 | −44, 11, 27 | 6.25 | −43, 10, 25 | 6.69 |
| R precentral gyrus | 4 | 47, −6, 33 | 4.97 | 47, −6, 34 | 5.25 | ||
| L STS | 21 | −53, −30, −8 | 4.82 | −54, −29, −4 | 5.51 | ||
| R IFG, triangularis | 45 | 45, 36, 17 | 4.60 | 45, 34, 20 | 5.60 | 44, 34, 24 | 4.87 |
| L IFG, triangularis | 45 | −48, 36, 26 | 4.96 | −56, 28, 18 | 6.85 | ||
| R MFG, dorsal | 9 | 26, 34, 40 | 5.55 | 30, 26, 40 | 5.92 | ||
| L MFG, dorsal | 9 | −40, 25, 46 | 4.82 | −42, 28, 45 | 5.28 | ||
| Dorsomedial SFG | 9 | 0, 36, 38 | 6.02 | 0, 36, 38 | 6.91 | ||
| L SFG | 8 | −24, 19, 47 | 4.72 | −25, 21, 47 | 5.80 | ||
| R middle temporal gyrus | 21 | 48, −18, −4 | 4.99 | 50, −18, −6 | 5.40 | ||
| L angular gyrus | 22 | −50, −51, 26 | 4.75 | ||||
| R inferior parietal lobule | 39 | 48, −59, 44 | 5.37 | ||||
| Limbic | |||||||
| R anterior hippocampus/amygdala | NA | 29, −13, −13 | 5.64 | 30, −14, −10 | 4.74 | −30, −14, −10 | 6.12 |
| L anterior hippocampus/amygdala | NA | 28, −14, −16 | 5.86 | ||||
| R posterior hippocampus | NA | 27, −26, −10 | 5.68 | ||||
| L posterior hippocampus | NA | −28, −32, −6 | 5.60 | ||||
| Subcortical | |||||||
| L caudate | NA | −7, 15, 6 | 6.15 | −8, 13, 9 | 7.23 | −10, 15, 7 | 7.88 |
| R caudate | NA | 9, 13, 9 | 6.15 | 9, 13, 9 | 6.97 | 9, 12, 7 | 7.65 |
| R putamen | NA | 30, 4, 8 | 5.51 | 27, 6, 8 | 6.57 | 29, 8, 10 | 7.27 |
| L putamen | NA | −22, 3, 6 | 5.63 | −22, 5, 4 | 6.40 | −22, 11, 4 | 7.23 |
| Medial thalamus | NA | 2, −8, 10 | 4.98 | 2, −8, 8 | 6.65 | 2, −8, 8 | 7.55 |
| R lateral cerebellum | NA | 48, −67, −48 | 4.65 | ||||
Abbreviations: ACC, anterior cingulate; bvFTD, behavioral variant frontotemporal dementia; BA, Brodmann area, CDR, Clinical Dementia Rating; IFG, inferior frontal gyrus; MFG, middle frontal gyrus; NA, not applicable; SFG, superior frontal gyrus; STS, superior temporal sulcus.