Figure 1.

Alignment of the carboxyl-terminal portions (including PH and basic c domains) of human cytohesin-1, cytohesin-2 (also known as ARNO; Chardin et al., 1997), and the homologous murine protein grp-1 (Klarlund et al., 1997). For comparison, the sequence of the carboxyl terminus of the β adrenergic receptor kinase (βARK) is given, which also contains PH and basic domains. The asterisk indicates the position of arginine 281. Arginine and lysine residues of the c domain are shown in bold letters.