Figure 1.

Alignment of amino acid sequences of human Mayven and Drosophila kelch proteins. The PPXPPX sequence at the N terminus of Mayven, which is a putative ligand for SH3 domains, is marked with dots. The alignment starts at aa 46 of Mayven and aa 146 of kelch (based on the numbering of kelch by Xue and Cooley (1993). The BTB/POZ domain is boxed. Boldface type marks the residues conserved between Mayven and the bric-a-brac transcription factor. These residues of bric-a-brac are sufficient and necessary for its dimerization (Chen et al., 1995). The kelch repeats are indicated by arrows, and the beginning of each repeat is numbered.