Table 1.

Distribution of HPV-16 variants in cervical biopsies from HPV-16 positive ICC cases

Branch	Variants	E6 substitutionsa				All HPV-16 cases	HPV-16 exclusivelyd
		10	14	78	83	Carriers (%)b n = 107c	Carriers (%) n = 69
E						54 (50.5)	28 (40.6)
	E-P	A	Q	H	L	49 (45.8)	23 (33.3)
	E-350G	-	-	-	V	4	3
	E-6994 A	-	-	-	-	1	1
	E-G131T	G	-	-	-	1	1
AA						59 (55.1)
	AAa	-	H	Y	V	58 (54.2)	37 (53.6)
	NA-1	-	H	Y	V	1	0
Af-1	Af-1	T	D	Y	-	1	0
Af-2	Af-2	I	D	Y	-	8 (7.5)	4 (5.7)

a) -: Residue identical to the E-P;

b) Percentages are shown only for variant branches and for the most common variant groups;

c) The total number of HPV-16 variants exceeds 107 because we included cases with infection by more than one variant;

d) Co-infections with other types excluded.