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. Author manuscript; available in PMC: 2008 Sep 21.
Published in final edited form as: Biochemistry. 2006 Oct 3;45(39):11867–11878. doi: 10.1021/bi060930g

FIGURE 2.

FIGURE 2

Sequence alignment between S. mansoni NACE and representative members of the ADP-ribosyl cyclase family. The amino acid sequence alignment (Clustal W 1.82) of the active site domains reveals the conservation of the invariant catalytic Glu (Glu202 ; bold) and other important residues of the active site such as Glu124 (bold) and Trp165 (shaded). The second invariant Trp residue present in the active site of all other members of the cyclase family (grey shaded) is replaced by His103 in SmNACE. The ‘signature region’ TLEDTLLGY (shaded) is present in all known CD38 orthologs.