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Schematic representation of the proposed regulatory function of SET7/9 on NF-κB and inflammatory gene expression. SET7/9 can stabilize and enhance p65 recruitment to a subset of gene promoters, and this is accompanied by increased H3-K4 methylation and augmented gene expression. Thus, SET7/9 may transform the promoter from a relatively “dormant” to more “active” state and thus allow efficient transactivation by NF-κB.
