Sequence comparisons.
A compares the amino acid sequence of
LA5 from 12 species. E180, D196, D200, D203, D206, and E207 are conserved in
all species. E208 is conserved in 8 of the 12 B compares the amino
acid sequence of human LA5 with the other six LA repeats of human LDLR. D206
E207 are conserved; E180, D196, D200, and D203 are somewhat conserved; while
E187 and E208 are conserved between different repeats. Boxed residues
are acidic residues that are conserved with human Residue numbering is for
human LA5.