Table 1.
Effects of topical GW2974 on DMBA-induced oral carcinogenesis in hamster cheek pouch a
| Group | Treatment | No. of animals | Visible Tumors |
Microscopic Observations |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Incidence % (No.) | No. | Size (mm3) | No. of hyperplasia | No. of dysplasia | No. of SCC | Incidence of SCC % (No.) | |||
| 2A | Negative control | 10 | - | - | - | - | - | - | - |
| 2B | Positive control | 30 | 80% (24) | 1.00±0.88 | 256.84±442.53 | 8.07±4.39 | 7.57±3.37 | 1.83±1.91 | 70% (21) |
| 2C | GW2974 (4 mM) | 30 | 43.3% (13)** | 0.57±0.82* | 62.08±58.99 | 5.73±3.09** | 6.80±3.74 | 0.67±0.99* | 40% (12)* |
| 2D | GW2974 (8 mM) | 30 | 36.7% (11)** | 0.43±0.63** | 50.50±54.88 | 5.30±2.89** | 5.97±2.62* | 0.43±0.68** | 33% (10)** |
a
The number and size of visible tumors, and the numbers of oral lesions (hyperplasia, dysplasia, and SCC) were expressed as mean ± SD. χ2 test was used for comparison of incidences of visible tumor and SCC, signed rank test for tumor size, and one-way ANOVA for the numbers of visible tumors, hyperplasia, dysplasia and SCC. Values of Groups 2C and 2D were compared with that of Group 2B.
*
p<0.05
**
p<0.01.