Table 2.
Feature | All Patients | Without Distant Metastasis (M0) | With Distant Metastasis (M1) | ||||||||||||
Low (n = 508, 91%) | High (n = 52, 9%) | P | Low (n = 435, 92%) | High (n = 38, 8%) | P | Low (n = 73, 84%) | High (n = 14, 16%) | P | |||||||
n | % | n | % | n | % | n | % | n | % | n | % | ||||
Sex | .004 | .015 | .5 | ||||||||||||
Male | 306 | 55 | 42 | 8 | 253 | 53 | 30 | 6 | 53 | 61 | 12 | 14 | |||
Female | 202 | 36 | 10 | 2 | 182 | 39 | 8 | 2 | 20 | 23 | 2 | 2 | |||
Age at surgery | 1 | .9 | |||||||||||||
<65 years | 281 | 50 | 29 | 5 | 231 | 49 | 21 | 4 | 50 | 57 | 8 | 9 | .5 | ||
≥65 years | 227 | 41 | 23 | 4 | 204 | 43 | 17 | 4 | 23 | 26 | 6 | 7 | |||
Karnofsky performance status scale | .6 | 1 | .4 | ||||||||||||
≥80% | 463 | 83 | 49 | 9 | 400 | 85 | 35 | 7 | 63 | 73 | 14 | 16 | |||
<80% | 45 | 8 | 3 | 1 | 35 | 7 | 3 | 1 | 10 | 11 | 0 | 0 | |||
Tumor extent* | .048 | .1 | .8 | ||||||||||||
pT1/2 | 336 | 60 | 27 | 5 | 306 | 65 | 22 | 5 | 30 | 35 | 5 | 6 | |||
pT3/4 | 172 | 31 | 25 | 4 | 129 | 27 | 16 | 3 | 43 | 49 | 9 | 10 | |||
Regional lymph node metastasis* | .002 | .02 | .2 | ||||||||||||
N0/pN0 | 477 | 84 | 42 | 8 | 418 | 88 | 33 | 7 | 59 | 68 | 9 | 10 | |||
pN1, pN2 | 31 | 6 | 10 | 2 | 17 | 4 | 5 | 1 | 14 | 16 | 5 | 6 | |||
Distant metastasis* | .03 | - | - | ||||||||||||
No | 435 | 78 | 38 | 7 | - | - | - | - | - | - | - | - | |||
Yes | 73 | 13 | 14 | 3 | - | - | - | - | - | - | - | - | |||
Grade of malignancy† | .005 | .2 | .1 | ||||||||||||
G1/2 | 430 | 77 | 35 | 6 | 386 | 82 | 30 | 7 | 44 | 51 | 5 | 6 | |||
G3/4 | 76 | 14 | 16 | 3 | 47 | 10 | 7 | 1 | 29 | 33 | 9 | 10 | |||
Histopathologic subtype‡ | .1 | .8 | .06 | ||||||||||||
Clear-cell RCC | 425 | 76 | 39 | 7 | 362 | 76 | 30 | 6 | 63 | 73 | 9 | 11 | |||
Papillary RCC | 42 | 8 | 6 | 1 | 36 | 8 | 5 | 1 | 6 | 7 | 1 | 1 | |||
Chromophobe RCC | 23 | 4 | 2 | <1 | 23 | 5 | 1 | <1 | 0 | 0 | 1 | 1 | |||
Spindle cell carcinoma | 3 | 1 | 2 | <1 | 1 | <1 | 0 | 0 | 2 | 2 | 2 | 2 | |||
Collecting duct carcinoma | 0 | 0 | 2 | <1 | 0 | 0 | 1 | <1 | 0 | 0 | 1 | 1 | |||
Unclassified RCC | 15 | 3 | 1 | <1 | 13 | 3 | 1 | <1 | 2 | 2 | 0 | 0 | |||
Type of surgery | .7 | .7 | .2 | ||||||||||||
Radical nephrectomy | 433 | 77 | 46 | 8 | 360 | 76 | 33 | 7 | 73 | 84 | 13 | 15 | |||
Partial nephrectomy | 75 | 14 | 6 | 1 | 75 | 16 | 5 | 1 | 0 | 0 | 1 | 1 |
P values < .05 are shown in bold.
TNM 2002.
Three patients with tumors of unknown grade.
Clear-cell (conventional) RCC versus other types.