Table 3.

Multivariate Cox Regression Analysis of DcR3 Expression and Clinical/Pathologic Features for the Prediction of Cancer Specific Survival.

Feature	Multivariate Cox Regression Analysis*
	Hazard Ratio	95% CI	P
DcR3 expression†	1.8	1.2–2.8	.006
Karnofsky performance status‡	1.5	1.0–2.3	.09
Tumor extent§	2.0	1.5–3.0	<.001
Regional lymph node metastasis¶	1.4	0.9–2.2	.1
Distant metastasis#	5.0	3.5–7.1	<.001
Grade of malignancy**	1.8	1.3–2.6	<.001
Histopathologic subtype††	1.1	0.7–1.7	.7
Type of surgery‡‡	2.1	1.0–4.6	.06
Sex§§	0.7	0.5–0.9	.02

CI indicates confidence interval.

^*Three patients with tumors of unknown grade of malignancy were excluded.

^†Immunohistochemical score ≥6 versus <6.

^‡<80% versus ≥80%.

^§pT3/pT4 versus pT1/pT2.

^¶pN1/pN2 versus N0/pN0.

^#M1/pM1 versus M0/pM0.

^**G3/G4 versus G1/G2.

^††Clear-cell (conventional) RCC versus other types.

^‡‡Radical versus partial nephrectomy.

^§§Female versus male.