Table 4.
Independent Variables | Tumor-Related Death | DSS | DFS | Metastases/Recurrence | Count (n) |
Fisher Exact/χ2 Test, P | Log-Rank Test, P | Log-Rank Test, P | Fisher Exact/χ2 Test, P | ||
Sex | .779 | .657 | .724 | .665 | 101 |
Localization (stomach vs small bowel) | 1.000 | .935 | .395 | .709 | 99 |
Tumor size (≥5 cm vs <5 cm) | .005 | .008 | <.001 | <.001 | 94 |
Mitotic rate (≥5/50 HPF vs <5/50 HPF) | .005 | .007 | <.001 | <.001 | 92 |
Fletcher (high vs non-high) | <.001 | <.001 | <.001 | <.001 | 95 |
Primary tumor state (unifocal vs not local) | <.001 | <.001 | <.001 | — | 101 |
CD34 (positive vs negative) | 1.000 | .670 | .590 | 1.000 | 88 |
Aktin (positive vs negative) | 1.000 | .611 | .236 | .319 | 68 |
Desmin (positive vs negative) | 1.000 | .935 | .601 | 1.000 | 48 |
p16 (positive vs negative, whole population) | |||||
Cutoff > 10% | .980 | .818 | .897 | .764 | 95 |
Cutoff > 20% | .813 | .596 | .745 | .926 | 95 |
Cutoff > 50% | .226 | .080 | .207 | .279 | 95 |
p16 (p16-positive high-risk GIST vs the rest) | |||||
Cutoff > 10% | <.001 | <.001 | <.001 | <.001 | 95 |
Cutoff > 20% | <.001 | <.001 | <.001 | <.001 | 95 |
Cutoff > 50% | <.001 | <.001 | <.001 | <.001 | 95 |
P < .05 were considered significant (bold face emphases).