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. Author manuscript; available in PMC: 2008 Sep 22.
Published in final edited form as: J Invest Dermatol. 2007 Jul 26;127(12):2807–2817. doi: 10.1038/sj.jid.5700970

Figure 3.

Figure 3

Tg skin grafts elicited anti-BM IgG in Wt and MHC I -/- mice. a. Tg skin grafts placed on Wt recipients elicited IgG that bound epidermal BMs in human and Tg skin (arrows, top and middle left panels), but not the skin of a Wt mouse (bottom left panel). Development of anti-BM IgG was unrelated to the grafting procedure (right panels). b: Longitudinal studies showed that Tg skin grafts placed on Wt (solid circles) and MHC I -/- (solid squares) recipients elicited high (640 to 2560) and durable (lasting ≥ 270 days) titers of anti-BM IgG that consistently appeared in the circulation of recipients 14 to 18 days after grafting. MHC II -/- mice (solid triangles) grafted with Tg skin did not develop anti-BM IgG. n=4/group in this longitudinal study that was representative of the aggregate work.