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. Author manuscript; available in PMC: 2008 Sep 22.
Published in final edited form as: J Invest Dermatol. 2007 Jul 26;127(12):2807–2817. doi: 10.1038/sj.jid.5700970

Figure 8.

Figure 8

Involution and loss of Tg skin grafts on CD4 -/- mice correlated with production of anti-BM IgG rather than exposure to CD4+ T cells (naïve or “immune”). Longitudinal studies showed that Tg skin did elicit anti-BM IgG in CD4 -/- recipients (solid circles), but that its production was delayed (day 44±5) in comparison to development of anti-BM IgG in Wt mice grafted with Tg skin (day 16±2). Accelerated graft loss in CD4 -/- recipients correlated with production of anti-BM IgG and progressed to completion within 12 to 15 days, a kinetic profile like that seen once specific IgG appeared in the circulation of Wt mice grafted with Tg skin. Adoptive transfer studies showed that involution and loss of Tg skin grafts on CD4 -/- recipients infused with naïve (solid squares) or “immune” (solid triangles) CD4+ T cells correlated better with the development of anti-BM IgG than exposure to CD4+ T cells. Arrows and brackets indicate the time points anti-BM IgG appeared in the circulation of CD4 -/- mice engrafted with Tg skin.