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Schematic representation of mutant lox66 and lox71 sites, which, after Cre-mediated recombination, result in a double-mutant lox72 site. Boldfaced sequences are mutated in comparison to the native loxP site. Solid arrows between pairs of lox sites indicate the relative Cre-mediated recombination efficiencies in the forward and reverse directions. “X” indicates recombination between two lox sites. Arrows with dotted lines depict the orientation of the 8-bp spacer.
