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Med SUMOylation reduces nuclear Smad levels. (A) Confocal images of gastrulating wild-type and lwr mutant embryos showing pMad and Med distribution. Embryos are oriented with dorsal up. (B) pMad protein distribution in embryos that are either wild-type or carrying a Ub:Med-SUMO, Ub:Med, or Ub:MedABC transgene.
