Skip to main content
. 2008 Sep 15;22(18):2520–2534. doi: 10.1101/gad.1678808

Figure 8.

Figure 8.

(A) A working model for FLH-1, FLH-2, and FLH-3 transcription factors. FLH-1, and/or FLH-2, in association with FLH-3, are proposed to directly bind to sequences containing the consensus a/gGGCGCCG in the promoters of lin-4, mir-241, and mir-48 during embryogenesis. This binding prevents the premature transcription of these miRNAs. Upon hatching, the FLH proteins are down-regulated, permitting the up-regulation of transcription of these miRNAs during larval development by the action of other factors, including putative transcriptional activators. (B) FLYWCH transcription factors regulate miRNA expression. Network depicting regulatory effects on miRNAs (rectangles) exerted by FLYWCH transcription factors (TFs) (circles). Solid lines are TF–Pmir interactions found by Y1H assays, dashed lines are miRNAs that change in expression in flh mutants, dotted lines are TF–Pmir physical interactions (no regulatory interaction determined), arrows are transcriptional activation, and blunted arrows are transcriptional repression.