FIG. 2.
Candidal rAls3p-N vaccine improved survival and decreased bacterial burden in mice with methicillin-resistant S. aureus bacteremia. (A) Survival of vaccinated or control mice (n = 22 per group from 2 experiments) infected i.v. with S. aureus 67-0 (2 × 107 inoculum), a methicillin-resistant, clinical isolate. *, P = 0.0001 compared to results for CFA alone by the log-rank test. The experiment was terminated on day 28, with all remaining mice appearing well. (B) Day-5 kidney or spleen bacterial CFU per gram of organ. n = 5 for CFA treatment; n = 7 for rAls3p-N vaccination. Median and interquartile ranges are shown. *, P < 0.03 compared to results for CFA by the Mann-Whitney U test.