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. 2008 Jul 21;76(10):4574–4580. doi: 10.1128/IAI.00700-08

FIG. 6.

FIG. 6.

rAls3p-N vaccine is efficacious in combination with aluminum hydroxide adjuvant. BALB/c mice were vaccinated subcutaneously with one or two doses of rAls3p-N (300 μg) plus aluminum hydroxide [Al(OH)3], with two doses of tetanus toxoid (TT) or rAls5p plus Al(OH)3, or with one or two doses of Al(OH)3 alone. (A) Mice were infected i.v. with S. aureus 67-0 (2 × 107 organisms) 3 weeks following the first dose or 2 weeks following the boost. n = 16 mice per group for two experiments for rAls3p-N; n = 8 mice per group for Als5p and TT. *, P < 0.03 compared to results for all other groups by the log-rank test. (B) Vaccinated (all with two doses) or control mice were infected i.v. with S. aureus 29213 (5 × 106 organisms), COL (1.4 × 108 organisms), 601 (1.3 × 107 organisms), or LAC (8 × 106 organisms). n = 8 mice per group. *, P < 0.05 compared to results for the control by the log-rank test. (C) Vaccinated (all with two doses) or control mice were infected 2 weeks following the boost with 8 × 108 S. epidermidis 35984 cells, 3 × 108 E. faecalis TX2484 cells, or 3 × 107 P. aeruginosa PA01 cells. (D) Mice vaccinated with only one dose of rAls3p-N plus Al(OH)3 or Al(OH)3 alone were infected 8 weeks later with S. aureus 67-0 (1.9 × 107 cells). *, P < 0.05 compared to results for the control by the log-rank test.