TABLE 2.
Serum and tissue iron levels of uninfected, 27- to 33-week-old wild-type, Hfe−/−, and β2m−/− micea
| Strain | Serum iron concn (mg/ml) | TIBC (mg/ml) | % Tf satb | [Fe] (mg/g [dry wt])
|
|
|---|---|---|---|---|---|
| Spleen | Liver | ||||
| Wild type | 1.62 ± 0.14 | 3.98 ± 0.24 | 40.8 ± 2.4 | 1,325 ± 65 | 559 ± 67 |
| Hfe−/− | 2.85 ± 0.10 (<0.01)c | 4.00 ± 0.20 (NS)c,d | 71.4 ± 1.9 (<0.01)c | 1,314 ± 190 (NS)c | 2,056 ± 278 (<0.01)c |
| β2m−/− | 3.68 ± 0.22 (<0.01, <0.01)e | 4.38 ± 0.30 (<0.05, NS)e | 84.5 ± 8.8 (<0.01, NS)e | 1,611 ± 35 (<0.05, NS)e | 2,770 ± 255 (<0.01, <0.05)e |
a
Values are presented as the mean ± 1 standard deviation for four or five mice per group. Statistical analysis is based on Bonferroni and Tukey tests.
b
Tf sat, transferrin saturation.
c
P value relative to wild type.
d
NS, no statistically significant difference (P ≥ 0.05).
e
P values relative to wild type, relative to Hfe−/−.