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Reducing Rap1 expression abolished HMVEC tube formation on Matrigel. HMVECs transfected with two distinct sets of control, rap1a, rap1b, or rap1a plus rap1b siRNAs were plated on Matrigel in vitro in the presence of 25 ng/ml FGF2, and tubular structures were allowed to develop for 12 h. (A) Representative images of HMVEC tube formation. Scale bar = 500 μm. (B) Quantification of total tube length. Bars show means ± standard deviations. ***, P < 0.001 (n = 3).
