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In vivo depletion of T-cell subsets. Absolute CD3+ CD4+, CD3+ CD8+, and CD20+ T-cell counts per mm3 of blood in macaques treated with the anti-CD4 antibody (OKT4A-IgG1) (A and B), left untreated (C), and treated with the anti-CD8 antibody (cM-T807) (D) are shown. Arrows represent times of inoculation of CM-T807 and challenge exposure to SIV. Results for MamuA*-01+ macaques in group 5 are shown in bold.
