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. 2008 Jul 30;82(19):9629–9638. doi: 10.1128/JVI.00893-08

FIG. 7.

FIG. 7.

Immune responses to SIV following challenge exposure. (A) Expansion of Gag181-189 (Gag181) tetramer-positive CD8+ T cells in blood of macaques from groups 1, 3, and 4 following challenge exposure to SIVmac251. (B) SIV Gag-specific IFN-γ, TNF-α, and IL-2 production in CD8+ and CD4+ T-cell responses in blood and lymph nodes from macaques 898L, 899L, 905L, 215M, 881L, 317M, 319M, 222M, 550M, 556M, 564M, 217M, 220M, 901L, 223M, 225M, 298M, and 299M, obtained at week 6 following SIVmac251 challenge exposure. (C) Quantification of immune responses in purified mononuclear cells collected from blood and lymph nodes of macaques 889L, 898L, 215M, 217M, 220M, 223M, and 22H obtained at week 24 (left). SIV Gag-specific IFN-γ, TNF-α, and IL-2 production in CD8+ and CD4+ T-cell responses at week 24 in blood of the same macaques.