FIG. 7.

CD4⁺ T-cell-mediated clearance of HSV-1 from the sensory ganglia and spinal cord does not require perforin. (A) Groups of B6, CD8-depleted B6, or CD8-depleted Pfp^−/− mice were inoculated i.vag. with HSV-1 and swabbed on the indicated days (d). Spinal cords (B), dorsal root ganglia (DRG; C), and hindbrain (D) were harvested on the indicated days for quantification of virus. **, significantly different compared to B6 controls (P < 0.001). CD8(−), depletion of CD8⁺ T cells by injection of specific antibody; SEM, standard error of the mean; Avg, average.