FIG. 8.

CD4⁺ T-cell-mediated clearance of HSV-1 from the sensory ganglia and spinal cord does not require Fas-FasL interaction. (A) Groups of CD8-depleted B6 or CD8-depleted B6-gld (gld) mice were inoculated i.vag. with HSV-1 and swabbed on the indicated days (d). Spinal cords (B), dorsal root ganglia (DRG; C), and hindbrain (D) were harvested on the indicated days for quantification of virus. Significant differences relative to B6 controls are indicated as follows: *, P < 0.05; **, P < 0.005. CD8(−), depletion of CD8⁺ T cells by injection of specific antibody; SEM, standard error of the mean; Avg, average.