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. 2008 Jul 23;82(19):9717–9729. doi: 10.1128/JVI.00782-08

FIG. 6.

FIG. 6.

Induction of neutralizing antibodies against CSFV. Neutralizing antibody (nAb) titers are given for serum samples derived from animals infected with cp CSFV Alfort-Jiv (group 1, animals 36 to 40) (A) or non-cp Alfort-p447 (group 2, animals 41 to 45) (B). Blood samples were taken at the indicated time points, and reciprocal neutralizing antibody titers were determined by a neutralization peroxidase-linked antibody assay as 50% neutralizing doses (ND50) using Alfort-p447 as the test virus. Animals 41 (day 21 p.i.), 42 (day 22 p.i.), and 45 (day 15 p.i.) were euthanized before the end of the animal experiment due to the occurrence of severe clinical symptoms. Note that high titers of neutralizing antibodies were induced after infection with cp CSFV Alfort-Jiv (all animals of group 1), whereas for animals infected with parental non-cp CSFV Alfort-p447 (group 2), only animal 44 developed significant titers.