TABLE 4.
Overrepresentation of transcription factor binding sites among lactic acid-responsive genesa
| Transcription factor(s) | Significance (log10P value)
|
||||
|---|---|---|---|---|---|
| pH 3 | Overall pH 5 | Common | pH 3 | Specific pH 5 | |
| Ace2p | (+) 3.89 | ||||
| Aft2p | (+) 6.17 | (+) 4.39 | |||
| (−) 3.15 | (−) 5.05 | ||||
| Cin5p | (+) 4.43 | (+) 4.02 | |||
| (−) 6.94 | (−) 5.51 | ||||
| Gcn4p | (−) 3.03 | (−) 3.18 | |||
| Gln3p | (−) 3.36 | ||||
| Hap1p | (+) 6.77 | (+) 3.30 | (+) 4.66 | ||
| Nrg1p | (+) 3.76 | (+) 5.94 | (+) 4.12 | ||
| Phd1p | (+) 3.04 | (+) 4.71 | (+) 3.22 | ||
| Rcs1p/Aft1p | (+) 11.82 | (+) 3.20 | (+) 8.90 | ||
| Skn7p | (−) 4.25 | ||||
| Sko1p | (+) 8.66 | (+) 7.69 | |||
| Sok2p | (+) 3.54 | (+) 3.02 | |||
| Ste12p | (−) 3.52 | (−) 3.61 | |||
| Stp1p/Bap1p | (−) 3.10 | (−) 3.97 | |||
| Sut1p | (+) 4.24 | ||||
| Swi5p | (+) 3.82 | (+) 4.68 | |||
| Tec1p | (−) 5.22 | (−) 4.47 | |||
| Yap1p | (−) 3.24 | (−) 4.14 | |||
| Yap7p | (−) 3.70 | (−) 4.84 | |||
a
Overrepresentation of transcription factor binding sites among lactic acid-responsive genes identified in a comparison of lactate-challenged and reference anaerobic chemostat cultures of S. cerevisiae CEN.PK 113-7D at pH 3 and pH 5. Overrepresentation of binding sites for each transcription factor is indicated in the upregulated (+) and downregulated (−) gene sets. Enrichment of transcription factor binding among the common genes and the pH-specific gene sets are also indicated. The significance of each category is numerically indicated as a log10 P value (as described in Materials and Methods [2]).