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. Author manuscript; available in PMC: 2008 Sep 22.
Published in final edited form as: J Am Chem Soc. 2007 Apr 11;129(17):5688–5698. doi: 10.1021/ja069003n

Figure 2.

Figure 2

DNase I footprinting titration experiments. The 117-bp EcoRI-PVuII restriction fragment from plasmid pBS was 3′-end-labeled at the EcoRI site with [a-32P]dATP in the presence of AMV reverse transcriptase. The products of the DNase I digestion were resolved on an 8% polyacrylamide gel containing 8 M urea. Drug concentrations are at the top of the lanes. Tracks labeled G represent dimethylsulfate piperidine markers specific for guanines. Sequences at the footprinting sites are indicated to the right of the gel.