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Acute tolerance: Development of a concept Simulated Plasma Profiles
Swanson J, et al. Clin Pharmacol Ther 1999;66:295.
Copyright © 1999, reprinted with permission from The American Society for Clinical Pharmacology & Therapeutics.
A. Study 1: Simulated plasma methylphenidate concentrations for a 20 mg total daily dose delivered by twice-daily (bid), flat, and ascending dosing regimens.
