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. 2005 Aug;14(Suppl 1):4–9.

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Copyright © 2005 Canadian Academy of Child and Adolescent Psychiatry

PMC Copyright notice

Proof-of-product study: PK profiles for OROS-MPH (Concerta) and IR-MPH (Ritalin)

(left side) A. Greenhill LL, et al. J Am Acad Child Adolesc Psychiatry 2003;42:1234

(right side) B. Swanson JM, et al. Arch Gen Psychiatry 2003;60:204. Copyright © 2003, American Medical Association. All rights reserved.

3B. The pharmacokinetic profiles from a 3-way crossover study of immediate release OROS-methylphenidate hydrochloride administered with a (high-fat breakfast) and without (fasting) food, and tid (3 times daily)-methylphenidate administered in the fasting state. OROS is a new oral once-a-day formulation to deliver methylphenidate by osmotic pump process based on OROS technology (ALZA Corp, Mountain View, Calif).