Figure 4.
Therapeutic efficacy of TG2 siRNA with docetaxel. Nude mice were injected i.p. with HeyA8 (A) or HeyA8-MDR (B) or RMG2 (C) cells and randomly allocated to one of following groups (therapy beginning 1 week after tumor cell injection): empty liposomes, control siRNA-DOPC, control siRNA-DOPC with docetaxel, TG2 siRNA-DOPC, TG2 siRNA-DOPC with docetaxel. The animals were sacrificed when control mice became moribund (3–4 weeks after starting therapy) and necropsy was done. Error bars represent S.E.