Skip to main content
. Author manuscript; available in PMC: 2008 Sep 22.
Published in final edited form as: J Med Chem. 2006 Jun 1;49(11):3354–3361. doi: 10.1021/jm060086s

Scheme 1.

Scheme 1

Reagents: (i) HCl, HON=CHCH2NO2; (ii) (CH3CO)2O, CH3COOK; (iii) POCl3; (iv) NH3; (v) H2/Pd; (vi) a) polyphosphoric acid, R'COOH, b) trimethylorthoformate, HCOOH, c) 1. R'COCl, 2. NaOH; (vii) 3-chloroperoxybenzoic acid; (viii) POCl3; (ix) RNH2.