Table 1. Analysis of quantitative changes in abundance of total cell proteins by GO category.
Proteins identified by LC-MS/MS were classified according to their GO annotations. The numbers of proteins in each class that were increased, decreased or unchanged (NC) in abundance are indicated along with the average fold-change for proteins in each class.
| GO Category | Up | NC | Down | Avg |
|---|---|---|---|---|
| Cytoskeleton | 16 | 6 | 3 | 3.10 |
| Transcription | 0 | 7 | 4 | 0.86 |
| Translation/Protein Biosynthesis | 1 | 3 | 27 | 0.68 |
| Metabolism | 1 | 6 | 3 | 1.03 |
| Cell Cycle/DNA metabolism | 0 | 1 | 7 | 0.54 |
| mRNA Processing | 2 | 12 | 6 | 0.98 |
| Protein Modification | 0 | 2 | 0 | 1.03 |
| Protein Catabolism | 0 | 2 | 1 | 0.83 |
| Neurogenesis | 10 | 0 | 0 | 3.77 |
| Nucleotide Biosynthesis | 0 | 3 | 0 | 0.95 |
| Protein Folding/Chaperone | 4 | 8 | 5 | 0.98 |
| Signal Transduction | 5 | 3 | 0 | 1.92 |
| Hydrolase Activity | 1 | 0 | 2 | 1.00 |
| Transport | 3 | 7 | 1 | 1.42 |
| Response to Stress/Oxidative stress | 0 | 0 | 2 | 0.69 |
| Mitochondrial categories: | ||||
| TCA cycle | 3 | 0 | 0 | 2.00 |
| Transport | 4 | 1 | 0 | 1.66 |
| ATP Synthetase | 2 | 0 | 0 | 1.82 |
| Electron Transport | 1 | 2 | 0 | 1.45 |
| Oxidative Stress | 0 | 1 | 0 | 1.22 |
| Protein Folding/Chaperones | 0 | 4 | 0 | 0.97 |