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. 2008 Jul 11;95(7):3510–3520. doi: 10.1529/biophysj.108.136721
Oks Probability that IKs channels are in the open state.
Iks Current through IKs channels.
Ik Sum of potassium currents.
INa Sum of sodium currents.
ICa Sum of calcium currents.
V Potential across the membrane.
C Membrane capacitance.
M The number of time steps required to reach the steady-state condition (usually equivalent to a few seconds).
a1Func Transition rate to open state as a function of V.
b1Func Transition rate from open state as a function of V.
C10,
C20, Initial probability of IKs subunit states.
C30,
Oks0
QMatrix The transition rate matrix for subunit states:
1 R = 1/(1-Oks0)*[C10C20C30]T
2 U = [1 0 0]T
3 Oks = Oks0
4 S = 0
5 F(1) = −α1*(1-Oks0)*R[1] ^ 4 + β1*Oks0
6 for i = 1 to number of timesteps
7 Oks = Oks-F(i)*dt
8 Ik = Ikr + Iks + Ik1 + …
9 Ik = Ikr + Iks
10 Iion = INa + ICa + Ik
11 V = V-1/C *Iion* dt
12 Q = QMatrix(V)
13 a1 = a1Func(V)
14 b1 = b1Func(V)
15 R = R + Q*R*dt
16 U = [[U + Q*U*dt], [1 0 0]T]
17 Ftemp = 0
18 for k = 1 to Min{i,M}
19 Ftemp = F(k)*(a1*U(1,k) ^ 4 + b1)*dt
20 end
21 Ftemp = −a1*(1-Oks + S)*R(1) ^ 4 + b1*(Oks-S) − Ftemp
22 F(i + 1) = Ftemp/(1 + dt*(a1 + b1))
23 if i > = M
24 S = S + F(1)*dt
25 F = F(2:M + 1)
26 U = U(:,2:M + 1)
27 end
28 end