FIGURE 4.

Depiction of the regions distal to the Taxol binding site that show changes in dynamics when Taxol binds. (A) Colored in red are the T1–T5 loops as well as a portion of H11 that show a significant increase in dynamics when Taxol binds. These loops make up the nucleotide binding site in β-tubulin. (B) These same loops also form the binding interface for α-tubulin of the next dimer along the protofilament. The molecular surface corresponding to the T1–T5 and H11 loops are shown in red and the contact surface in α-tubulin is shown in cyan.