TABLE 3.
Mutation patterns causing discordances for non-nucleoside RT inhibitor genotypic resistance interpretations
| Interpretation |
|||||||
|---|---|---|---|---|---|---|---|
| Drug | No. discordances |
A | H | R | V | No. sequences* |
Mutation patterns |
| DLV | 75 | R | S | I | I | 23 | 101E (23)† |
| S | S | R | I | 15 | 108I (15) | ||
| S | S | R | S | 14 | 106I (14) | ||
| S | R | R | R | 12 | 181I (12) | ||
| S | R | R | I | 8 | 230L (8) | ||
| EFV | 22 | S | I | R | I | 10 | 230L (6) |
| 106A (4) | |||||||
| R | S | I | I | 9 | 101E (8)† | ||
| NVP | 49 | S | S | R | I | 15 | 108I (15) |
| S | S | R | S | 14 | 106I (14) | ||
| R | S | I | I | 8 | 101E (8)† | ||
| S | R | R | I | 8 | 230L (8) | ||
DLV, delavirdine; EFV, efavirenz; NVP, nevirapine; A, ANRS-3-02; H, HIVDB-8-02; R, Rega-V5.5; V, VGI ver 6.0.
Mutation patterns responsible for uncommon patterns of discordance are not shown. In addition to those listed, delavirdine was responsible for three discordances (SIRI-3), efavirenz for four discordances (SRRI-2, RRSR-1, SRSS-1), and nevirapine for four discordances (SIRI-3, SRSS-1).
The number of sequences with well-defined mutation patterns (last column) often does not add up to the total number of sequences because only those sequence containing common mutation patterns are listed. Listed patterns are nonoverlapping: sequences matching two patterns were counted only once. K101E caused fewer discordances for nevirapine and efavirenz than for delavirdine because this mutation was frequently accompanied by G190A, which causes resistance to nevirapine and efavirenz but not delavirdine.