Skip to main content
. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Chem Res Toxicol. 2008 Jul 26;21(8):1503–1508. doi: 10.1021/tx800133d

Table 2.

Tri-, tetra-, and pentachlorophenols as substrates for hSULT2A1.

Molecule Structure Sulfation at 10 µM (nmol/min/mg) Sulfation at 50 µM (nmol/min/mg) Relative activity (%)a
2,3,4-Trichlorophenol graphic file with name nihms58763t10.jpg 10.1 ± 1.0 30.9 ± 0.3 55.2
2,3,5-Trichlorophenol graphic file with name nihms58763t11.jpg 14.6 ± 0.8 47.7 ± 0.7 106.4
2,3,6-Trichlorophenol graphic file with name nihms58763t12.jpg 10.5 ± 0.7 28.4 ± 0.8 65.9
2,4,5-Trichlorophenol graphic file with name nihms58763t13.jpg 14.4 ± 1.3 46.0 ± 1.1 81.7
2,4,6-Trichlorophenol graphic file with name nihms58763t14.jpg 9.3 ± 0.1 26.2 ± 0.2 44.7
3,4,5-Trichlorophenol graphic file with name nihms58763t15.jpg 12.1 ± 1.0 38.2 ± 0.7 89.3
2,3,4,5-Tetrachlorophenol graphic file with name nihms58763t16.jpg 16.0 ± 0.5 67.1 ± 1.7 160.9
2,3,4,6-Tetrachlorophenol graphic file with name nihms58763t17.jpg 10.1 ± 1.5 21.6 ± 0.2 51.2
2,3,5,6-Tetrachlorophenol graphic file with name nihms58763t18.jpg 4.0 ± 0.3 12.9 ± 2.6 29.5
Pentachlorophenol graphic file with name nihms58763t19.jpg 13.2 ± 0.2 48.0 ± 0.9 91.2
a

Relative activity is expressed as a percentage based on the ratio of the rate of sulfation of the chlorinated phenol at 50 µM to the rate of sulfation of 50 µM DHEA under the same assay conditions.