. Author manuscript; available in PMC: 2008 Sep 23.

Published in final edited form as: J Am Chem Soc. 2006 Mar 8;128(9):2778–2779. doi: 10.1021/ja057498v

Table 3.

Aymmetric Mannich-type Reaction with Boc-Imine^a graphic file with name nihms-64019-f0005.jpg

entry	R		product	time(h)	yield^b (%)	dr^c (anti:syn)	ee^d (%) (anti,syn)	8^b(h) (%)
1	cyclo-hexyl	6a	7a	14	77	1:5	ND,94	6
2	i-propyl	6b	7b	19	70	1:3	95,90	5

All reactions were performed using 5 mol% 2a and 2 equiv of 3a in THF at 0.3 M unless noted otherwise.

Isolated yield.

Determined by the ¹H NMR of the crude mixture.

Determined utilizing chiral HPLC.

ND = not determined.